Get this medication by mouth with or without food as directed by your doctor, generally each 4 to six hrs as necessary. This medication might be taken with foods if belly upset occurs. Drink lots of fluids any time you use this medication unless or else directed by your health care provider.
Promethazine with Codeine Oral Option contains promethazine, a phenothiazine. Phenothiazines are involved with dystonic reactions, specially in pediatric sufferers who've an acute illness affiliated with dehydration.
Tend not to give this medicine to any person younger than eighteen decades old who lately had surgical procedure to eliminate the tonsils or adenoids.
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The opioid antagonists, naloxone and nalmefene, are distinct antidotes for respiratory melancholy resulting from opioid overdose. For clinically important respiratory or circulatory depression secondary to codeine overdose, administer an opioid antagonist. An antagonist should not be administered during the absence of clinically sizeable respiratory melancholy. Since the period of opioid reversal is predicted to become fewer than the duration of motion of codeine in Promethazine with Codeine Oral Remedy, cautiously keep an eye on the individual until eventually spontaneous respiration is reliably reestablished.
Employ other supportive measures (which includes oxygen and vasopressors) in the administration of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias would require advanced lifetime-aid procedures. Gastric emptying can be practical in removing unabsorbed drug.
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Promethazine with Codeine Oral Resolution is made up of promethazine, a phenothiazine. Phenothiazines are associated with dystonic reactions, notably in pediatric clients who have an acute ailment involved with dehydration.
Codeine in oral therapeutic dosage won't typically exert major outcomes around the cardiovascular procedure.
Propulsive peristaltic waves in the colon are decreased, while tone may be increased to The purpose of spasm causing constipation. Other opioid-induced outcomes could contain a reduction in biliary and read more pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.
Promethazine has an elimination 50 %-lifetime of 10-14 hours, with excretion of metabolites showing up inside the urine and feces. The sulfoxides of promethazine and N-demethylpromethazine will be the predominant metabolites appearing from the urine
Therapy of Overdose Treatment of overdosage is driven by the overall clinical presentation, and includes discontinuation of Promethazine with Codeine Oral Option alongside one another with establishment of appropriate therapy. Give Major awareness towards the reestablishment of suitable respiratory exchange as a result of provision of a patent and protected airway plus the establishment of assisted or controlled air flow.
Employing this medication with other medication that slow your breathing can cause dangerous Unintended effects or Demise. Talk to your medical professional in advance of employing opioid medication, a sleeping capsule, a muscle relaxer, or medication for anxiousness or seizures.
Tend not to flush medicines down the rest room or pour them into a drain Unless of course instructed to take action. Adequately discard this merchandise when it truly is expired or no longer essential. Consult your pharmacist or area squander disposal business.